Two sample MR report
SPATA20_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0671374 | 0.0739351 | 0.4152080 |
| Weighted median | 6 | 0.0142632 | 0.0070348 | 0.0426099 |
| Inverse variance weighted | 6 | 0.0114819 | 0.0057931 | 0.0474798 |
| Simple mode | 6 | 0.0157080 | 0.0095911 | 0.1623977 |
| Weighted mode | 6 | 0.0156272 | 0.0097986 | 0.1716332 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.127617 | 4 | 0.8898661 |
| Inverse variance weighted | 1.697767 | 5 | 0.8891810 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0497819 | 0.0659291 | 0.4922215 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003267 | 0 | TRUE | 0.085343 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
